What are you painting? TruColor/Accupaint/Star paints (same formulation) will adhere beautifully to clean polystyrene. If you're painting brass, metal, or polyurethane resin, you'll need to prime first to get a really good bond.
Tim O'Connor
My experience has been hit and miss with Tru Color. I've had issues with it adhering to clean styrene/ABS shells. It certainly won't adhere to Scalecoat 2 paint where I used it to match the decals I had that were made to match AccuPaint. The Tru Color matched perfectly but wasn't happy sticking to the base paint. I'm not a fan of the Tru Color product. I did, however, recently try some Tamiya paints and was mightily impressed - this coming from a hardened Scalecoat user :)