Like the low-side gons owned by other y'all railroads (e.g., ACL, SAL), the Southern's cars were intended primarily for limestone service. In the only two photos I have of these cars were the loads are visible, they're carrying crush limestone. However, open-top cars were versatile and the Southern doubtless used their low-side gons for anything and everything that would fit in them and didn't require weather protection.
The Maine Central also had similar low side gons in the #17000 series. The limestone trade was a prime reason why.